研究成果： |
课题组以小鼠为模式动物，综合利用细胞及分子生化实验技术，结合行为学测试，高通量测序技术手段研究大脑皮层发育的调控机制、神经精神疾病以及代谢类疾病神经发育缺陷的致病机制，先后于Molecular Therapy、J. Neuroscience及Cell reports等知名杂志发表论文10余篇，主持国家自然科学基金青年基金、博士后科学基金面上项目及吉林省科技厅面上项目。 代表性论文： 1. Junjie Wu, Dezhe Qin, Ziqi Liang, Qiang Liu, Min Wang, Ye Guo*, and Weixiang Guo*. Dysregulation of astrocyte-derived matrix gla protein impairs dendritic spine development in pyridoxine-dependent epilepsy. Molecular Therapy, 2025 Apr 2;33(4):1785-1802. Q1 (Commentary: Vitamin K as an add-on therapy in pyridoxine-dependent epilepsy. Houten SM. 2025. Molecular Therapy. 33 (4) 1318-1319) 2. Yinghao Liu#, Min Wang#, Ye Guo#, Lei Wang, Weixiang Guo*. D-2-hydroxyglutarate dehydrogenase governs adult neural stem cell activation and promotes histone acetylation via ATP-citrate lyase. Cell Reports, 2023 Jan 31;42(2):112067. Q1 3. Ye Guo#, Xing Luo#, Weixiang Guo*. The impact of amino acid metabolism on adult neurogenesis. Biochemical Society Transactions, 2023 Feb 27;51(1):233-244. Q2 4. Ye Guo, Junjie Wu, Min Wang, Xin Wang, Youli Jian, Chonglin Yang, Weixiang Guo*. The metabolite saccharopine impairs neuronal development by inhibiting the neurotrophic function of glucose-6-phosphate isomerase. Journal of Neuroscience, 2022, 42(13): 2631-2646. (Featured Research) Q1 5. Yuhan Wang#, Ye Guo#, Changyong Tang#, Xiu Han, Mingyue Xu, Jing Sun, Yifei Zhao, Yiwen Zhang, Min Wang, Xiaofeng Cao, Xiaojuan Zhu and Weixiang Guo*. Developmental Cytoplasmic-to Nuclear Translocation of RNA-Binding Protein HuR is Required for adult Neurogenesis. Cell Reports, 2019 29: 3101-3117. Q1 6. Ye Guo#, Xu Chen#, Ruxiao Xing, Min Wang, Xiaojuan Zhu* and Weixiang Guo*. Interplay Between FMRP and lncRNA TUG1 Regulates Axonal Development through Mediating SnoN-Ccd1 Pathway. Human Molecular Genetics, 2018 27:475-485. Q2 7. Ye Guo, Xiaoxiao He, Lu Zhao, Lin Liu, Huifang Song, Xudong Wang, Jiahui Xu, Xingda Ju, Weixiang Guo* and Xiaojuan Zhu*. Gβ2 Regulates the Multipolar-Bipolar Transition of Newborn Neurons in the Developing Neocortex. Cerebral Cortex, 2017 27:3414-3426. Q1 8. Mingming Lai#, Ye Guo#, Jun Ma, Huali Yu, Dongdong Zhao, Wenqiang Fan, Xingda Ju, Muhammad A. Sheikh, Yousra S. Malik, Wencheng Xiong, Weixiang Guo* and Xiaojuan Zhu*. Myosin X regulates neuronal radial migration through interacting with n-cadherin. Frontiers in Cellular Neuroscience, 2015 9, 326. Q2 带“#”标注为共同第一作者,带“*”标注为通讯作者或共同通讯作者。 |
