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生物药学系

王迪

日期:2023-02-28 点击数: 来源:

   名:

王迪

 

      称:

教授

最高学位:

博士

   件:

jluwangdi@jlu.edu.cn

工作地点:

生命科学楼583

研究方向:

1)食药用菌质量评价、营养分析及产品研发;

2)天然产物功效筛选、作用机制研究及产品研发;

3)病理机制挖掘以及基于疾病靶点的快速检测试剂盒研发。

教育经历:

20099-20139月:香港大学,李嘉诚医学院博士;

20079-20097月:吉林大学,生命科学学院硕士 (提前毕业)

20039-20077月:吉林大学,生命科学学院学士。 

工作经历:

20223月至今:吉林大学,生命科学学院,唐敖庆“讲座教授”;

20219月至今:吉林农业大学,植物保护学院,教授;

20179月至20219月:吉林大学,生命科学学院,教授;

20159月至20179月:吉林大学,生命科学学院,副教授;

20158月至20213月:吉林农业大学,作物学,博士后(李玉院士)

201311月至20159月:吉林大学,生命科学学院,讲师。

荣誉与奖项:

1. 2024年度国家科技进步一等奖,排名第10

2. 2023年吉林省青年科技特别奖;

3. 2022年度高等教育国家级教学成果奖,二等奖,排名第6

4. 2021年国家高层次人才;

5. 2018年度高等教育国家级教学成果奖,二等奖,排名第7

研究成果:

王迪,1984年生,吉林大学唐敖庆讲座教授,博士生导师,国家高层次青年人才,国家食用菌产业技术体系岗位科学家,吉林省科协第十届委员会委员,吉林省生物化学与分子生物学会常务理事。获得2024年度国家科技进步一等奖,20182022年度国家级教学成果奖二等奖,主讲课程入选首批国家级一流本科生课程(2020年)。担任Frontiers in ImmunologyFrontiers in Nutrition杂志副主编。主持国家重点研发计划子课题、国家自然科学基金项目、吉林省重大科技攻关招标等国家、省部级项目18项,校企产学研合作项目11项,累计科研经费超过1500万;在Science AdvancesMolecular CancerCarbohydrate Polymers等杂志上发表SCI检索的原创和综述类学术论文171篇,谷歌学术H-index45;获授权发明专利31件,转让至企业8件;同9家药企建立长期合作关系,获批保健品2个,完成8个销售过亿元的中药、生物药大品种的二次开发工作。培养博士及硕士研究生100余人。

代表性科研论文(*通讯作者)

以通讯作者/第一作者发表SCI论文171篇,H-index45,其中中科院141篇;以第一发明发人获得授权发明专利16项;作为主编/副主编出版教材/专著7部。部分代表作如下:

1) Zhina Wu, Rui Liu, Jianai Chen, Xueying Cai, Jingzheng Yi, Jiasi Wang*, Di Wang* Min Hu*. An enzymatic cleavage-triggered minimally invasive nanosensor for urinebased detection of early atherosclerosis. Science Advances, 2025, 11, eadu7614.

2) Xin Zhang, Shuai Liu, Keyi Wu, Lili Shu, Yu Li*, Lanzhou Li*, Di Wang*. Structural characteization and anti-colorectal cancer activity of a fucogalactan purified from Ganoderma tsugae. Carbohydrate Polymers, 2025, 352, 123203.

3) Yaqin Zhang, Yingjie Cheng, Chenfei Zhao, Jianai Chen, Zhina Wu, Jiasi Wang,* Di Wang,* Simultaneous detection of protein and nucleic acid biomarkers with a CRISPR-based assay, Chemical Engineering Journal, 2025, 503: 158452.

4) Jie Hao, Yanfeng Zhu, Yongfeng Zhang, Lanzhou Li, Zhige Li, Lu Wang, Yidi Qu, Liangliang Qi, Hailong Yu,*, Di Wang,**, Structural characterization and hypolipidemic activity of a hetero-galactan purified from Sanghuangporus vaninii based on modulation of TLR4/NF-κB pathway, Carbohydrate Polymers, 2025,347,122702

5) Yaqin Zhang, Jianai Chen, Zhina Wu, Chenfei Zhao, Rui Wang*, Zhiping Li*, Jiasi Wang, *, Di Wang * CRISPR/Cas enzyme catalysis in liquid-liquid phase-separated systems, Advanced Science, 2024, 2407194

6) Xin Liu, Mingyuan Dong, Yuan Li , Lanzhou Li , Yongfeng Zhang, Chunyue Wang, Ning Wang* , Di Wang**Structural properties of glucan from Russula griseocarnosa and its immunomodulatory activities mediated via T cell differentiation, Carbohydrate Polymers, 2024, 122214.

7) Ying Zhou, Lanzhou Li, Zhen Sun, Rui Liu, Yanfeng Zhu, Jingzheng Yi, Yutong Li, Min Hu*, Di Wang**, Structural characterization and osteogenic differentiation-promoting activity of polysaccharide purified from Chroogomphus rutilus, Carbohydrate Polymers, 2024,

8) Andong Zhou, Haoyu Cheng, Honghan Liu, Lanzhou Li, Zhiyuan Chen, Shanshan Chen*, Chunyue Wang*, Di Wang*, Neuroprotection of low-molecular-weight galactan obtained from Cantharellus cibarius Fr. against Alzheimer’s disease, Carbohydrate Polymers, 2023, 316:121033

9) Jiyu Song#, Yongfeng Zhang#, Yanfeng Zhu, Xinghui Jin, Lanzhou Li, Chunyue Wang, Ying Zhou, Yutong Li, Di Wang*, Min Hu* , Structural characterization and anti-osteoporosis effects of polysaccharide purified from Eucommia ulmoides Oliver cortex based on its modulation on bone metabolism , Carbohydrate Polymers, 2023,120601

10) Shanshan Teng, Yongfeng Zhang, Xinghui Jin, Yanfeng Zhu, Lanzhou Li, Xiaowei Huang, Di Wang*, Zhe Lin*, Structure and hepatoprotective activity of Usp10/NF-κB/Nrf2 pathway-related Morchella esculenta polysaccharide, Carbohydrate Polymers, 2023, 120453

11) Dongjie Li#, Qiubo Chu#, Shimiao Wang#, Lanzhou Li, Bo Dou, Jiawei He, Yaping Tian*, Di Wang*. ZhenQi FuZheng formula-mediated improvement of hematopoietic function in cyclophosphamide-treated mice via the upregulation of macrophage colony-stimulating factor concentrations. 2020, Clinical and Translational Medicine. 2020, 10, e256.

12) Chunyue Wang#, Xueying Cai#, Siyu Zhai, Yongfeng Zhang, Wenji Hu, Yizhi Zhang*, Di Wang* Neuroprotective effects of verbascoside against Alzheimer's disease via the relief of endoplasmic reticulum stress in A beta-exposed U251 cells and APP/PS1 mice. Journal of Neuroinflammation 2020, 17: 309

13) Fan’ge Kong#, Xue Jiang#, Ruochen Wang, Siyu Zhai, Yizhi Zhang*, Di Wang* Forsythoside B attenuates memory impairment and neuroinflammation via inhibition on NF-kappa B signaling in Alzheimer's disease. Journal of Neuroinflammation. 2020,17: 305

14) Wenji Hu#, Juan Wang#, Weiying Guo#, Yange Liu, Ziang Guo, Yuge Miao, Di Wang*. Studies on characteristics and anti-diabetic and -nephritic effects of polysaccharides isolated from Paecilomyces hepiali fermentation mycelium in db/db mice, Carbohydrate Polymers, 2020 Mar 15;232:115766

15) Yidi Qu, Bo Dou, Hor Yue Tan, Yibin Feng*, Ning Wang* Di Wang*, Tumor microenvironment-driven non-cell-autonomous resistance to antineoplastic treatment, Molecular Cancer, 2019, 16:69

代表科研项目(5年)

1. 国家食用菌产业技术体系岗位科学家专项,2024.1-2028.12350万元;

2. 吉林省优秀青年基金项目,2023.1-2025.1230万元;

3. 国家重点研发计划子课题负责人,2019.7-2024.650万元;

4. 横向课题,吉林桑黄生物科技集团有限公司,2024.1-2027.12100.0万元;

5. 横向课题,源合盛(吉林)药业有限公司,2023.7-2025.1250.0万元;

6. 专利转让,北京中京丰创科技有限公司,2019.11-2038.11, 80.0万元。